HYOSCINE POISONING : PILOCARPINE AN EFFICIENT ANTIDOTE. A MAXIMUM DOSE.

N-acetylcysteine as an antidote in methylmercury poisoning.

Methylmercury is a ubiquitous environmental pollutant and potent neurotoxin. Treatment of methylmercury poisoning relies almost exclusively on the use of chelating agents to accelerate excretion of the metal. The present study demonstrates that oral administration of N-acetylcysteine (NAC), a widely available and largely nontoxic amino acid derivative, produces a profound acceleration of urinar...

British anti-lewisite as an antidote for acute mercury poisoning.

Need for antidote for aluminium phosphide poisoning.

Human toxicity of aluminium phosphide occurs due to the toxic effects of phosphine which is liberated in stomach on ingestion (1). The effect is worse in the presence of hydrochloric acid in the stomach. It is widely absorbed from gastrointestinal tract and has cytotoxic action as it inhibits mitochondrial respiration. It affects almost all systems i.e. gastrointestinal, cardiovascular, respira...

Atropine or hyoscine in treatment of acute organophosphate poisoning?

The abdominal wall was infiltrated with lignocaine and incised in the mid-line. 3 litres of semisolid food was removed from the stomach and exploration revealed gross gaseous distension of small and large bowel, with infarction of the small bowel, and gas bubbles in the mesenteric veins. The ischaemic bowel was decompressed and packed with hot towels without any improvement and the patient died...

Can Galantamine Act as an Antidote for Organophosphate Poisoning? A Review

Organophosphate compounds are commonly used as insecticides in rural areas and powerful warfare agents by military personnel. These agents inhibit cholinesterases especially acetylcholinesterase and accumulate acetylcholine causing muscarinic, nicotinic and central nervous system manifestations. Currently, drugs such as atropine, oximes and benzodiazepine are used to treat these symptoms. But t...